Everyone is going to die
In all the interviews with the MCU brass, directors and actors, it sound like the next two Avengers are going to end the MCU as we know it. That probably means a lot of people are going to die. Probably all of them.
The Proof: With all the contracts coming up, chances are that Marvel’s gonna let the big salaries go. That said, everyone will probably go out heroically, as that’s the only way to truly end the first 3 Phases. We’ve invested 22 movies into this, so the payoff has to be worth it. What’s greater than Thanos wiping out everyone and the Avengers making the ultimate sacrifice?
Then with Kevin Feige saying that Phase 4 will be a whole new direction for the MCU, with a new feeling, what’s better than to clean the slate, starting with making Spiderman the cornerstone. But this doesn’t mean that everyone’s gone for good.
As the stones can destroy, they can also create, so maybe some of the characters come back, but they look different (like a recast actor) different, or their back stories are changed. This might be how the MCU moves forward.
Guess we’ll just have to wait and see which one of these are correct.